There's the broad strokes and tiny strokes to consider on the subject.
With multiple speaker cabs, a lot of what people are hearing at gig volume is the crosstalk between speakers usually manufactured with some rather loose tolerances or uneven wear (depending upon the wiring) and the resonance of the cab itself.
Not all speaker cabs of the same format are voiced the same, which contributes to confusion and debate when discussing the subject.
Take the same speakers and put them in a 1960a, Soldano Slant, and a Vai Legacy cab using the same amp to drive them in the same room. Before you place a mic on them to add an additional variable, play them. Since they are all closed back slant cabs, they should sound the same, but they don't. It's a matter of the internal volume of the cab, bracing, mounting of the speakers, baffle board attachment, and seal of the back panel that produce tonal/timbral differences.
If you have a particular cab format with an open back, it's going to sound different than a sealed closed back and a removable closed back. My brother was a bit of a mad scientist in the early 70s. I remember him taking precise measurements of a friend's Marshall 4x12, constructing a replica of the measurements and experimenting by changing removable versus truly sealed versus open back. Ported front, ported back, versus non ported. Fiberglass filled versus no fill. Changing baffle mounting styles. With the same speakers and same wood in the same room, you could hear differences. That left an impression on me.
The 1 speaker cab format removes a lot of variables from achieving a tone as you remove the crosstalk between speakers and the manufacturing variance/wear between them.
Even then though, certain speakers just sound great in certain cabs but not as good in other cabs so there is a certain amount of handshake between them that happens when you find a combination that sounds good to your ears.
Add in the coloration of one or multiple mics, different rooms, different cab & mic placement in those rooms, and different signal chains, and the equation becomes quite complex.
Use your ears. When you find something pleasing, narrow down your path first by deciding if you want to try out different speakers in the same cab format, different cabs using the same speaker, or different cab/speaker combinations using the same mic or mic blend.
There's few shortcuts in making art.