I don't have exactly the same problem as zolaive, but after some test at home with my strat I can confirm that there is some huge difference depending on the Input 1 setting (direct on the axe FX II panel)
with Left only, it sounds "normal" to me
with sum L+F, it is all overdriven, sounds awful (prode, All i want is you etc...)
with Stereo, it sounds really clean and the volume is a lot lower, not enough grit.
I didn't see it before, but the change of input 1 have NO impact on the setting on the axe FX itself.
I have sum L+R when I load the preset in Axe edit ( Left only in the Axe FX input config), but if I change that; input 1 remains at Left only in the Axe itself (or any setting there).
Change of input 1 in Axe edit have in my opinion no effect at all on the sound !!!!
It seems that only the change with the Axe panel itself have the awaited impact on the sound.
Is it normal or am I crazy
. it is very Strange. Bug with Axe edit ??
I also tried the input trim. It cleans a little the sound as awaited, as it can simulate the fact to plug in low input of the amp for example.