With regards levels, and set-ups.
I run the Matrix flat out - best way with power amps IMO, however you need to reduce the feed from the Axe to compensate. Ultimately I dont suppose it matters whether youreduce the Matrix of the Axe levels.
i set the Matrix full, AND the Axe full. I then set the "gain" level in the Global out down as far as it goes and play into the Marix (you dont need speakers attacked like a valve power amp - so the speakers are not at risk during set-up).
The "signal" light on the Matrix lights up with a -9db output (it is the output signal NO input - so High Axe/Low Matrix or Low Axe/High Matrix give the same result). Into an 8 Ohms cab, that equates to 30W ish. I set this with my loudest patch, but my solo vol not used - and then raise the gain in global until that signal light starts to light. That way Im pushing 30W into my cab when both Matrix and Axe front knobs are set to max. Engaging my col solo boost upps the signal by 3db - giving me 60W which is what my cab will handle.
Doing it this way - rather than turning th MAtrix down (or axe front knob for that matter) is Im not tempted to "just turn it up a little more". When knobs are full up, Im at max O/P for my cab.
if your cab is higher - 120W (2 x V30s) for instance, then you can increase you "global Gain" level once you have the flashing light. 3db = double power. So, set your loudest patch - even with max vol boosts too. Raise the global gain until the light flashes - thats 30w, then you can go abnother 6db up (+3db = 60W, +6db = 120W) if your using a 4x12 with V30s - you have a 240W cab - so youcan go up another 3db.