I read where some users don't upgrade their firmware and then end up jumping a few versions, if they finally decide to update.
I use my AXE FX II for live playing. With that said, I don't ever skip a firmware update. I update as soon as they are released. I know it will always be better. Maybe sometimes there is mention of a little bug, but it is fixed so fast, I can honestly say I never experienced one. And it does not bother me, at all, that I may have to tweak my presets because something changed, that I don't like. And if I don't like the new firmware, (it's never gonna happen), I make backups, so I can always restore back to the previous version and presets.
IMHO there are always improvements with new firmware updates.