My approach so minimalist there's really no preset to write home about.
My methodology is to find an amp I like (suggestions are several Fender models, Tucana, Shiva). More than likely the amp caught my ear through exploring factory presets. Then just turn everything off except for compression, amp, cab, reverb. All I really adjust are BMT on the amp.
I find most "normal" presets are written to showcase an amp (i.e., Tucana and Shiva) so selected cab and IR are usually just fine. Also compression and reverb aren't anything crazy.
The goal is to hear as much of the guitar as possible (I don't really like the reverb up too much). The guitar and amp/cab get you like 99% there.