I have found through many years of personal experience working with synths, that the less harmonic content the 'trigger' note contains going into the synth block, the less the probability that a note will be hard to read during pitch translation.
Rich harmonics at the synth's input forces the synth block to see the original note with it's accompanying sympathetic harmonics simultaneously (too many notes) which produces instability of a fixed note producing churps, glitches or note hopping for lack of a better term.. turning down the guitar's tone control minimizes harmonic content and can help with this somewhat...
Also, without compromise, precision picking and focused technique is an absolute necessity!
P.S. I have found that... Dialing back the guitar's tone control has proven to be beneficial in getting the pitch block to track and convert with more stably and helps with tuner stability as well.
I Hope this info helps you to achieve synergy!
I Hope this info helps you to achieve synergy!