I use the AxeFX 3 With my Orange RV50 with a 2x12 cab using the 4 cable method, in the same patch I created simulated RV50 with both having identical time based fx loops, simulated amp/cab and effects out to FOH, They sound identical. They both share the same pre signal chain because my guitar is plugged into the AXEFX3 then it’s split, one to the front of the real Orange and the other to the Simulated. Hope this makes sense. I did this for redundancy reasons, if either unit, the real amp or the AX3 fails to work I have an instant back up, they would both have to fail at the same time for the show not to go on, Plus it looks cooler on stage with an amp, let’s be honest. I will say having the AX3 going into and through the real amps FX loop makes it sound amazing!! The best of both worlds, and a killer pedal board to boot (FC-12) and I don’t have to use a mic on the cabinet. Thank you Fractal!!!