Maybe being a noob is part of your challenge (no offence intended). Google speaker phase.. lots of explanations.What do you mean by out of phase? bit of a noob sorry
The mackie does make the axefx sound really sick at loud volumes in a band practise situation but at quiet volumes both through the mackie and normal home speakers (logitech z506) the sound isn't very nice!
I listened to ur soundcloud test and ur right.. it sounds bad. I'm not a high gain guy, but there are folks here that are that can help clean up the mud.
I'm guessing that the difference you hear in the Mackie at practice vs home us is what is called the FM (fletcher-munson) effect. It's a challenge we all face when creating presets that sound awesome at home or via phones, yet suck when we crank to gig levels. It's how we humans process different frequencies at differ spl's. We hear things differently at different volume levels (spl). When one is experienced enough, one can "allow for" the FM effect when creating presets.