I disagree - if I was going to use a drive pedal, I'd put it in the effects loop.
Kind of like putting ketchup on a steak.
I use Distortion, Fuzz, OD, Mid Boost & Treble Boost pedals in front of the Axe II (& Ultra) & they sound
excellent.
Regardless of the great drive pedals inside - external pedals definitely add another dimension to the Axe.
I would hardly call using a Skreddy Screwdriver “ketchup on a steak” :?
YMMV