To be fair, most physical amps you put in a mic in front of need some work done to get them to sit in a mix. It’s more rare to NOT have to tweak them than it is to tweak them. Ideally, sure, it’d be great to just dial in the front panel of an amp and call it a day, however, there’s a reason why people have blown weeks in major recording studios on just getting a guitar sound. It’s also another reason people hate dealing with mic’ing a cab, because there’s a millions spots where it sounds like ass and a few where it sounds great.
The AxeFX is basically taking the post-EQ work done at a mixing desk and putting in the same space as the amp. I know one thing for sure, I CERTAINLY do not miss adjusting a mic, running back to the control room, checking the mic, running out to the mic again, tweak the amp, back to the control room to check, rinse and repeat. I can sit my fat ass down in my studio and not get up for 8 hours straightThat said, I think Leon Todd did a video this week where he loaded up a Cameron, didn’t even touch the settings and it was a gig-worthy tone. It’s certainly possible.