DLC86
Fractal Fanatic
Even though those are excellent suggestions, I think that's not what he was asking.Yes, makes a difference, depends on what you are going for, the preamp cut will give you a nice cut of the muddiness and flubby sound before it gets virtually amplified, the cab will cut AFTER it's amplified, which reduces much of the 'boom' and feedback inducing frequencies, and giving you a much better space in the mix, as you are not fighting with your bass kick and bassist.
Some amps benefit from cuts in both, but with the latest FW there is little need for it.
I'd recommend trying a preamp cut with say a fender or Mesa styled amp and see wha it does, and a cab cut to your personal taste.
Looking at the post he quoted I assume he was talking about the preamp tab in the cab block, not the amp's preamp.