I use the AxeFX just like i do my dual rec, basically one or two channels of meat and potatoes raw af screaming digital recreation of an LOUD amp, with ML recto 4x12 IR.
DD-500 at the end of the chain usually to use it's global EQ to do heavy filtering and post-chaos containment, midi switchable per preset connected to the switcher. OD-20 into DS-1, for the OD-20 octave fuzz and heavy octave. the sound godzilla would make if trent reznor tied him to a bed and had his way with him. TC sentry is set up in the most badass way that i don't think is possible with any other gear anywhere, it has a send/return system on it, where the clean DI guitar goes into the input before it goes into the switcher, so the clean guitar signal opens and closes the gate, but passes right through true bypass to the switcher input. the gate itself is in one of the loops of the switcher which you can put anywhere in the chain per preset, so i've got octave distortion going into a phaser going into a runaway delay going into a DS-1 set on Kurt Cobain...absolute apocalypse, signal to noise ratio of basically 1:1. With the gate at the end of the chain, when you stop playing, dead silent. you can tap the strings and open the gate percussively and the avalanche is still going on underneath. or you can move the gate right before the last clean delay and only get trails of the insanity. it's like using 4-cable method, but twice, or squared, or whatever. 4 cable method inside a loop switcher. it works perfectly, and instantly. wire tap is on the output to hold up to 8 hours of dumb noise ideas, bluetooth accessible via my gawdam cell phone.
the dual expression pedal goes into the ES-8 as TRS control but can be data swapped in the ES-8 to get spit out as midi CCs to control stuff in the AxeFx via a midi cable. volume pedal can get put at the front, or back, or wherever as well, per preset. input buffer, output buffer, on/off, per preset. (on for clean sound to get through all the boxes and still sound chimey, off for distortion to let the fuzz rape the signal properly.) the MS-50G lets you chain internally up to 6 effects at a time, but they didn't say you can do 6 of the same effect in row. YOU CAN DO 6 OF THE SAME EFFECT IN A ROW.