are you running straight into the synth block, or do you have something in front? i can play an open E without any trouble, but i have an amp block and a filter in front of the synth block. set the amp block to quite gainy and then send that to a filter block with the top and bottom rolled off and then into the synth block. the pitch detection is on the global input, but the envelope detection is on the input to the synth block. i know it doesn't make any sense, but it does seem to work - here is a preset i made where the synth block is also running into an amp, but it has an amp in front as well - scroll to the end and you can hear me hit a long open E...
if you still have trouble, you can also shift the synth block down an octave (within the synth block itself) and play an octave higher
sim