Like a lot of people here most likely, having tube amps as well as an Axe FX has let me try a lot of combos of power amp units (fryette lxII and SD PS700), real cabs, FRFR cabs, and studio monitors; as well as playing in ears at my church and only going direct with the Axe FX.
I’ve been hard pressed to find a substantial difference between a tube amp through a cab compared to the axe fx going into a power amp and into a cab. Most people seem to take the element of legit air being pushed as “the real deal” sound. The axe fx is more than capable of amazing tones with amazing feel through a power amp, even solid state like the PS700, and through a cab pushing real air.
I don’t find it significantly, or even remotely, different than running a real tube amp. We’re already at the point that people thinking there’s a significant enough difference to justify one being better than the other is most likely psychosomatic.
Yea, I agree. There's a bunch of different ways to get great sounds these days, and at this point, I think I've tried just about every way of amplifying the Axe Fx (as a pedalboard into the front of tube amp, 4CM with a tube amp, W/D/W with all tube amps, FRFR stereo, Axe into a power amp into a cab, Axe into the power amp of a tube amp into a cab...)
and as long as you understand how to set up each scenario, they all sound
excellent! The same? No, but they shouldn't. A set of studio monitors shouldn't be the same as a 4x12 W/D/W rig pumping air right next to you. But each setup really sounded great, and the Axe handles them all equally well. I could be totally fine with any of those solutions in the long term. My most often used setup? Axe straight to the board, done and done.
A lot of folks get really hung up on this stuff, as to which sounds better, "more realer", etc etc ad nauseam. They can all sound great, but absolutely
none of them will sound better than you, as a player, sounds. One of my favorite overdrives, the Blackstone Overdrive, has some good advice printed on the circuitboard of the pedal: