Yup! I can honestly say it's the best FRFR solution I've ever heard other than a pair of HS8s; I've never heard the Axe FX sound more 'authentic' through anything else. It gets unbelievably loud and has an amazing balance (which I think is a consequence of the 12" speaker size but what do I know). I wouldn't (and don't) really use it to practice though, in terms of power handling it's the equivalent of 2 full stacks or something like that, which is overkill for my room. I still practice out of crappy old KRKs, but on the occasions where I go out and play with people I don't think it can be beat... unless you run two of them in stereo, lol.
Discounting loudness, the only thing I think could compete with it is a pair of HS8s, maybe paired with a sub. They might even be a bit more practical for a bedroom but I wanted the final boss of FRFR solutions for other occasions, which it certainly is, so it was well worth it to me.