If money was no issue, I'd like to try an Adrian Belew Parker Fly.
Otherwise, I'm pretty happy with my Godin LGXT. It fits your specs, besides:
- other PUs (Seymour Duncan Jazz and Custom Custom)
- no middle PU (which I prefer)
- has also 13-pin output (for guitar-to-midi/guitar synth)
My Ernie Ball JP6 is insanely versatile. I rarely use any other guitar because it pretty much does everything except the neck single coil on a strat. I used the JP6 for almost every preset in the Every Axe Fx II Preset videos I did on YouTube, regardless of the style. Couldn't recommend it more highly.
I use a Hamer Steve Stevens that I have a single coil sized neck humbucker, a middle single coil and a bridge humbucker. Via the aid of coil taps and an on/off switch for the middle pickup I yield 17 possibilities.
+1 on Parkers. I endorse them. But only because I love them and had been playing them for over 10 years before endorsing them.
Checkout my soundcloud page for samples recorded with Parker and Axe FX.
This may not be helpful, but I believe the AFX ll can make almost any guitar sound the way one wants - seriously. Having said that, I believe a guitar with quiet/noiseless pickups is very important for any medium to hi-gain players. There is enough high-quality EQ and filtering within the AFX ll to make a Fender sound like a Gibson & vice versa, especially when distortion is involved... Just my opinion, no flames please! )
This may not be helpful, but I believe the AFX ll can make almost any guitar sound the way one wants - seriously. Having said that, I believe a guitar with quiet/noiseless pickups is very important for any medium to hi-gain players. There is enough high-quality EQ and filtering within the AFX ll to make a Fender sound like a Gibson & vice versa, especially when distortion is involved... Just my opinion, no flames please! )
Fender American Deluxe Strat HSS with the S1 Switch.