On my patch, im running a FAS Modern at a drive of 11 o clock bass at 1 mids cranked and treb at 11, master at 7 and level at 0dB (turning the output knob down)
From there Im using 2 cabs blended, a German V30 and a Citrus V30 both with a low cut of 100 and levels at -4.
The drive is really just personal preference, but I also have a PEQ right after the amp block with 700 at -2dB