If you have your FOH sounds (with Cabs) coming at you from the wedge, plus your backline sound through a 2x12 from Output2 without Cab sim, you will have problems.
I had the simliar thing by mistake, when the sound guy thought I looked like I wasn't getting enough volume from my backline ( 1x12 Scumback and 1x12 EVM thru a GT800). He gave me some of my FOH through my wedge, which was very confusing as the two are not exactly the same even though I've got cam sim that equate to my backline cab sound. I didn't know he'd done this until the break when I complained about how it was all sounding. He took my guitar out of the wedges and it was fine again.
I can't think why you'd need to have two cabs like this. If you work with good PAs, then you can leave all your backline at home rather than buy your own wedge! I prefer my own guitar backline - old school... and adjust the balance with everything else by turning up/down the GT800 - and the sound guy.
routing in axe will have signal with cab sims going to wedge.
I will use wedge for monitoring -- vocals/keys/guitar and maybe bass (I think he can give me a line out).
Just to note -- we typically (90% of the time) do not mike up. The clubs we play have no FOH system. You show up -- set up and play.
Our current vocal monitoring system sucks and the keys which is also not going through the PA sometimes with the organ gets a little out of control.
If I am going to add an extra monitor -- this might be a better solution for me.
The backline will still be my primary amplification source (wedge/cab or traditional) -- I like to feel the music hitting me from behind (old school). I just like it that way. Hearing guitar coming up from a monitor in front of me (without an amp behind me or near me) just does not feel right to me. It never has -- and I suspect it never will.
I might end up just putting the keys and guitar into the mixer to feed through the monitors without going through PA so we can hear it mixed with the vocals -- just to give the keys and me a better sense of the overall mix.
It is tough -- we have very strong vocals in the band (except for me -- I can't carry a tune for the life of me) with a lot of fairly complex harmonies -- but sometimes (principally because of monitoring - I think) the keyboard vol creeps up and he takes over the mix and drowns everybody out) --- Great player but he is a little difficult to deal with and very set in his ways -- so I need to find solutions - this might one.
Regardless -- for me BL amplification is what I like and I am use to and I am not going to change (I am a little difficult as well )
I just might end up using the 2x12 and keep the wedge or cube for home use or when we are forced to play in very tight places.