When we built the NL12, we spent "some time" building prototypes, adjusting cab volumes, adjusting port area and port length ... and the different woods available .. and before you ask, no, all the panels in the NL12 and 212 are not made from the same stuff!
If you then add to that the various drivers we tried (hint: to anyone who has been to the factory, the test driver rack is the one behind the door as you go through to speaker final assembly ) including getting drivers built specially, with slight tweaks from the standard recipe ... there's a lot of variables.
I forget how long that whole process took now ... it was at least 6 months, numerous afternoons of sound testing with known musicians, blind tests where we got them to play visually identical cabs and choose the one they liked etc. We only finally signed it off when all the testing panel consistently picked the same design as being "best".
If you think you can take a standard off-the-shelf driver, stick it in totally different cabinet and get the same results ... then you will most likely be disappointed. You may of course find yourself a winning combination, if so well done, but the chances of it sounding the same as our cab, are minimal. That said, there is nothing wrong with experimenting, its fun and you get some interesting reults, sometimes you might even like them
Saying "I didn't like these speakers in a guitar cab" isn't really relevant to what we do though, as it certainly isn't the same cab, or made from the same woods, or even necessarily exactly the same driver.