You might get a difference in tone from jostling a loose connection while you’re reversing the cable, but not from which end is tied to which side. The cable and any of its imperfections still present the same impedance in both directions.
A blurb from the article below regarding reversing direction and how it can change impedance (search on the words "reverse cable"). Not saying always, but it seems like things can easily slide into what some might deem cork-sniffing territory though. A point that has been made on the forum and in many an article that compares expensive cables to more economical ones.
Ihttps://sonicscoop.com/can-guitar-cables-really-change-tone-hear-decide/
I still wonder though if impedance is the only factor that could modify the tone when reversing cables. And if there are other factors, how (in)significant they might be.
Despite my best efforts to better spend my time, this has been an interesting topic. Anyway, on to the deliberation of other, more often than not, inconsequential minutiae. Think I'll stick to my testing on reversing my guitar and the impact of playing left-handed. The delta in the results is much easier to measure and only requires a single experiment.