Im running same setup (Axe II > Matrix GT1000FX > NL212) but with cab sim ON! Yap, that’s right, and it sounds a blast!
That’s exactly the problem I had when cab sim was OFF.
My first thought was 'did he just say FRFR and cab sims OFF!?'
Granted I'm not familiar with the particular gear he's got, but that sounds like the problem to me.