Apologies for the novel but trying to provide the reasoning down this path.
I'll provide you something to try, as I attempted something yesterday after
months of similar EMI and ground noise issues/troubleshooting you are facing. It appears to have corrected it for me.
My noise issue was with traditional amps in the room but I think the same would apply here. I want to add that it was getting worse using a quick connect panel I was using in the same rack as the effects gear (bypassing the quick connect, it was quieter but still present). I got the hint to try this regarding a noise gate discussion on a youtube video and mentioned an isolation transformer.
Note, I'm not running a dual amp setup that would typically require the device mentioned below but figured I would try it.
I have a Radial Twin-City A/B/Y switch that uses an isolation transformer on the output. When using the guitar direct into the Twin City and then output to the rest of my effects/amp chain, the noise was finally gone but had a bit of tone suck going on. Reading Radial's site,
https://www.radialeng.com/blog/eliminate-noise-in-your-guitar-rig, at the bottom of the page it recommended using a buffer before the isolation transformer "Transformers are passive devices. If you send your guitar directly into a transformer, the tone will change. By first buffering the signal, you will dramatically reduce the tonal effect of the transformer.".
After adding a buffer I had in front of the Twin-City, I was noise-free and had all my original tone that I wanted.
I am no electrical expert so somebody else will have to chime in as to why this "potentially" worked. My suspicion is that the isolation transformer stopped passing the EMI that was appearing on the ground of the guitar cable. Can't guarantee this will work for you but perhaps another avenue to look at. Perhaps there are other cheaper options for isolation transformers for 1/4" cables, etc.. that I'm not aware of.