Totally disagreeing with these suggestions.
My advice would be "fixing" the issue at preset level, with global EQ neutral. Then, if necessary, use the Global EQ to finetune your overall tone when gigging / rehearsing.
The reason that I disagree is that when you take down frequencies at global level on forehand, you're starting off on the wrong foot when editing presets. If the preset's too dark, you'll bump Treble/Presence but in fact you're compensating for the Global EQ settings.
Also, the Global EQ affects all tones, so your clean tones, synth tones, simulated acoustic presets etc. will be "crippled".
Now there's not a lot to fix probably. For example, create a simple preset consisting only of an Amp block with Friedman BE, and a Cab block set to #103. Increase Treble and Presence in the Amp block to 5 or 6, depending on the guitar. That's all. At this point you should have a great beefy 'rock" tone. Not raspy, not shrill, and not too dark either. If not, there's something wrong with your configuration or your connections.
And as mentioned by Scott and others, if you create tones using headphones or low level at home, the result will always be too shrill at gigging volume. Dial in your tones at gig volume and then fight the urge to adjust them (increase bass/treble) when you're at home.
I know I know. It's not textbook. I agree. It just seems to work for me for whatever reason. And when I do this, I just find that I have a more accurate starting point. So I guess what I'm saying is that these eq adjustments get me to what I consider a "neutral" starting point so I am much more accurate when I mess with amp tone knobs or preset level eq. I just feel like the treble with global eq at 0 is not the correct starting point and overhypes highs from the get go. To each his own.