Cab being used with the power amp?
If you have a head or heads, please also list (at least) one that sounds really good. Have you run another preamp through the 2:100? If yes, which one? Settings on everything please?
The Axe can simply "not click" (right away, or at all) for some people. Some require a bit of time doing some tweaks, and these can be very minor ones. The psychological angle should not be entirely dismissed either IMO. There are enough knowledgeable people here who can, and are willing to, assist you with this. If you do not mind a bit of work, and giving this some time and real effort, it is entirely likely it will be resolved. If it seems a lost cause, then the psychological + emotional aspect is likely playing a heavy part, and it might be a matter of simply taking a step back for a day.. or, sell and move on. Once again though, there are people who are very capable and able to provide help, though it will take some effort