That's a fantastic setup.Not necessarily.
In my environment I use converters and stage boxes which accept concurrent connections of devices which run at different (!) sample rates. Therefore I don‘t have to care about the sample rates of devices used simultaneously on stage or in a project. I am able to run devices at, say 96 kHz, together with „slow“ devices at, say 48 kHz.
And - best of all - without any DA/AD conversion in between.
For example:
https://rme-audio.de/de_adi-192-dd.html
That few have access to, I suspect.
Do you have coax to TOSLink converters on all your Axe-Fx's in this setup? Or do you use AES?