AlbertA
Fractal Fanatic
IDK. It seems like asking the Axe Fx III to serve as an audio interface is a bit much. I'd suggest getting a good audio interface. No? I don't know. What do I know? I've never used it as an audio interface. I have plenty of high end ones so I don't need to. But it's a speciality tool.
The Axe-Fx II and III are pretty good audio interfaces. The analog front end is nice and quiet.
Adjusting the latency offset for me is pretty much a one time thing in my setup so a minor inconvenience.
I bet most people wouldn't even notice once they bring down "USB Buffer Size" in the Axe-Fx III - try something like 32.