Earlier in the conversation,
@CipherHost asked about another USB cable to try.
Cables can deteriorate with use, so I'd certainly swap it for another known good cable, and see if that resolves this issue.
If it were me, I'd probably try exporting a preset from the AF3, testing the USB cable further.
Any chance you've added either a new hardware device or a new application around the time this stopped working?
I can't recall, but if you haven't already deleted AxeEdit, I would do that, and try reloading a fresh version.
We are all hopeful you'll find the key to this frustrating puzzle and get it back to normal.
Cheers,
Lee