No luck on unplugging and replugging the USB cable in. I've narrowed it down to only happen when there's >~50% load on the axe-fx and MIDI on a decent interval being sent to the axe-fx. Again, this never happened before updating from 12.09 to this 12.11 on the axe-fx and axe-edit to 1.06 and haven't changed anything on my wiring or computer, but given the above comments that it's a known issue with others on previous versions, I'll just switch back to using a different I/O for the time being. Appreciate the heads up! Has anyone at Fractal narrowed down if this is this an error on the hardware side of the axe-fx or something that can be eventually fixed via firmware?