The Axe FX 2 XL+ is so good that many of the most respected guitarists in the world use it. The capability of the hardware you have isn't in question. You've certainly got good gear. Most of the questions will revolve around what you plan to do with it (what sounds do you want, styles of music, etc).
As has been said more times than I can count, read the manual. You have to know something about how the unit works to make it work like you want. The manual will tell you how to connect your system, disable cab blocks, etc, in order to match what you're using. You'll have to settle with investing as much time as you have money to get the best from your dollars. You don't have to learn all of it to get started, but everything you learn adds to your ability to build... and your ability to work through "it doesn't sound right" sort of situations.
A Strat sounds like a Strat, so if the player you're trying to emulate uses some mega-hot humbucker you're going to struggle. This is true in the regular amp world and will be true here. This box comes closer than most to making one guitar fill many roles, but there is a reason different guitars and pickup configurations are out there. Start with the one that has a history of making the sort of sounds you want and you'll be a lot closer to smiling.
Perhaps you can search out some presets from users who use a Strat and get the sounds you want. The search function here is your friend. Also, the Axe FX Wiki is a goldmine of help and information. Just Google Axe FX II Wiki and you'll find it. We had Yek canonized for his involvement there, so make sure to kiss his ring if you happen to see him.
Feel free to ask questions here. These folks are outstanding in their knowledge and willingness to help. Reading the aforementioned manual will help you avoid abusing their tolerance levels. But rest assured, we were all new to this once and remember well how mind-boggling the Axe FX can be. Take your time, and you'll do just fine.
