I've just been focusing hardcore on the firmware DynaCabs, really fully taking advantage of what they have to offer. There's such a variety of tone color in the different speakers that FAS has chosen to include. My MO is often to use two mics out of alignment, often the 57 with the Soyuz aligned further back and about 6 dB lower, until the pick attack is nice and soft. Then I'll move the mics until I have just the right character.
I've gotten really into so many of the cabs so far, the Bassman, the G12T-100, the Orange, the Tweeds, the Champ, the SLO, the straight and slanted Rectifiers, the 5150 III, the 1960TV, and the CJ11. And what's funny is I feel like it would only take a tiny bit of time to figure out where I'd find good uses for the remaining DynaCabs.
One thing that is huge to me and (as far as I know) completely unique to the Axe-FX III is the ability to work with trimmed IRs in a movable mic sim. I like to remove any obvious reflections, testing by applying wide vibrato to really high notes, so I often settle on a length of 512. The ability to set that length first is huge, then to build the character of the tone knowing this is what the end result will be. I used to use movable mic plugins, carefully setting a tone and capturing a traditional static IR, then I'd trim it in the Axe-FX III, which would of course alter the low end of what I had already worked hard to perfect. The introduction of firmware DynaCabs allowed me for the first time to have what-you-hear-is-what-you-get tweaking with the IRs already trimmed, and that is very powerful to me.