I tweak to what sounds good to my ears, then refine that with a full mix, it won't be DRASTICALLY different, but it will likely NOT sound as awesome on it's own.
My overall philosophy is that the less the soundman has to touch my sound is the better for both me and the band - the audience will then hear the same I hear, and the band sounds good. The soundman gets to focus on other things and make the vocals sound great, and all is well with the world.
I prefer to have a sound that works in context, so there is more consistency from gig to gig, and the soundman just has to adjust levels. May sound not as great as on it's own, but that's what presets are for - I can have a preset that sounds great on it's own too for me to jam, the soundman can get the 'band context' version of that preset and it's a win-win all round.