The Motu UltraLite Mk3 is my main audio interface.When I record guitars I always use the Axe-FX USB in order to record both the dry and wet signals, but when monitoring or recording vocals and acoustic instruments I use the Motu.
It is also useful for playing live with a laptop for backing tracks, microphone for vocals, and eventually a keyboard player. The output of the Motu goes to the PA and acts a s a mixer for all the signals.
I use them a lot but, as you may imagine, I do not use the COSM AMP/CAB/FX at all. I only use the V-Guitar Modeller part and I connect it to the rear stereo input of the Axe-FX for processing.
The VG-99 or GP-10 Bass Modeller connected to the Axe-FX Bass Amp and the Bass Cab Packs (pack 11 and ML-USA-Bass) sounds amazing. Impossible to differentiate from a real bass. From Steve Harris to Billy Sheehan or Geddy Lee, it's all there.
My dream is that the Axe-FX had V-Guitar. Like the Roland VG but with Fractal Audio supreme quality. Can you imagine? We could be swapping different guitar bodies, pickups an all kind of string and bowed instruments and synths with the same facility as we are currently exchanging IR's at the CAB block. Besides Cab Packs, there would be Pickup Packs, Bass Packs, Acoustic Guitar Packs, Violin Packs, Banjo packs, Stratocasters from all ages...
Electro-Harmonix is recently starting to show that this could be made even without the need of a divided pickup (SYNTH9, MEL9, KEY9, B9, C9) They still haven't got into guitars or pickups modelling, only synths and keyboards, but this is opening possibilities.