Thanks all. I think the purpose of my initial question got diluted, but I still think there is value in knowing how to set the modeled amp
+cab to match what I hear in my studio from the real amp+cab. I also agree that the real goal, which becomes 100% subjective and song dependent, is to ultimately do whatever sounds good, but I wanted a matching reference base line.
To put a final end to this chapter, I compared the CabClone from my MarkV to both real amp+cab and to the accurately simulated all AxeFX preset. What I found is that CabClone played through my studio monitors (same chain as the AxeFX) requires absolutely NO EQ to sound very close to the real amp. This makes 100% sense to me, and further is what I was expecting from the modeled amp+cab with NO EQ, which is the only reason why I started this thread to begin with. We have debated all the reasons why the modeled sound doesn't match and that's fine, and maybe (most likely) the CabClone ultimately may have built-in low/high pass filters although there is no way to know and it is sort of moot.
I figured it was interesting to mention that CabClone is good to go right from the XLR output, although surprisingly, there is some sort of conventional wisdom that CabClone is no good. I tend to disagree based on the above although I didn't play it in a live and loud environment.