LOL - depends on whether your amp is SS or Tube. For SS it's generally NOT best to run them "full up" - at least not into a cab, and not without gain staging them first. These knobs on the front of a power amp are NOT volume controls, they are input attenuators. Turning them full up or at minimum does NOT stop the amp from reaching its rated (continuous) power output levels. What they do is control the amount of input voltage required to drive the amp to rated levels.I think it's best to run a power amp pretty much full up and control volume from the pre-amp or mixer - exploits the maximum clean headroom of the amp. Depends I suppose on those sweet spots that you find sometimes - maybe the amp likes a hotter level at input meaning you have to wind down the output vols .... or there's a spot that sounds good in the amps volume setting that isn't full up. As long as it's never set low enough to clip or high enough to pop a speaker .....
Can't beat a good definitive answer huh?
Also clipping does not occur at "low" settings. Clipping occurs when the amp is unable to meet output levels resulting from input voltage exceeds the maximum supported by the amp and generally occurs when driving them too hard. This most often happens when your amp is not LARGE enough to handle the expected output. Rule of thumb is that a power amp should be able to produce from 1.5 -> 2.25x the continuous/program/rms rating of the speaker. For a 300w 8-ohm speaker, to handle transients, your amp should produce between 450 -> 675w at 8-ohms. You should not blow ("pop") or clip anything with that range amp. You should then gain-stage the amp (search the forum pls.. I provided detailed post on it some time ago) so clipping does not occur. That point is where the knobs should end up on the amp when done. That might be considered the "sweet spot".
I seldom use Tube power amps as they color the sound and have a different gain-staging process.