I used an HD500 happily for years, but toward the end, the digital amp sims drove me nuts. I bought a Tech 21 Blonde and used that for my amp sim with the HD for FX, volume, etc. I liked that so well, I graduated to an Ethos, which did better Fender cleans than the Blonde (IMO) and was two channels, giving me more tonal range. A very hot setup.
When I got the Axe II, the HD got sold but I kept the Ethos. So my backup is a Pedaltrain Jr. with the Ethos (non-powered), CMAT Mods Deluxe Signa Comp, Timmy, Wampler Ecstasy, and Boss DD-6 delay. However the Axe has never required a backup, so this stuff just collects dust. I'm keeping it all, though, as sometimes I get calls for quickie gigs with zero setup time. Drop the Pedaltrain on the floor and go. Or just the Ethos running on batteries.