Tried your preset.
The cab preamp is of no use here. You're competing with a powerful traditional guitar cab in the room. That's not something you're going to solve easily.
You are using a user cab, so we can't test / get the exact sound you have.
You have chosen one of the brightest Amp types in the unit without bottom end: the AFS. And you've increased Treble. Don't know what guitar you are using, but if you are using a Strat, that must be very harsh through FRFR.
Also because you are not applying High Cut in the Cab block. And the Tube Drive drive block, with Tone turned up, only increases that brightness more.
So I would do the following:
AMP:
Change your amp type to another less-bright Marshall with more bottom end.
Change Speaker Compression back to default.
If you're playing your FRFR system really loud with the band, set Output Mode in the Amp block to "SS PA + Cab" instead of "FRFR".
CAB:
Make sure you're using the right IR for the task.
Change High Cut in the Cab block to 5500 Hz. That will sound dull at home but makes you cut through better in the band.
Change AIR and ROOM LEVEL in the Cab block to zero.
Play with Proximity in the Cab block to add bottom-end thump, and make sure you're not cutting bass on your FRFR system.