I think cubase and most other DAWs has a function to measure the round trip latency with outboard gear and compensate automatically.
I think that is true when the equipment is connected digitally. However, the AX8 can't reamp via USB, and so you have to do it in the analog realm. Cubase doesn't "know" how long it takes the signal to travel through the AX8, so I had to just manually.
If there is a way for cubase to "know" the roundtrip times in the analog realm, please let me know how to set this . However, I think it only can do that when dealing with plugins and digitally connected equipment.