Programming Patch Changes in Ableton Live

Hey guys!
This is my first post here, so please excuse me if it's in the wrong category.

So, here is what i want to do:
I have our bands' show running in ableton live through a Focusrite Interface (incl. click track, backing tracks and in ear-monitoring feed).
How can i control the patch changes of two Axe-Fx II XLs in that same session? Can i send those MIDI-changes through USB when I'm NOT using the AxeFx as playback engine or do I have to do this via MIDI connection?
 
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