Hi everyone, I had the privilege of chatting with M@tt about this topic after Dweezilla 2012 and wrote some notes down with the intent we'd eventually post these Tips & Tricks to the forum. So, here ya go. Matt may clarify or amplify, since he has not edited these. Yek may want to add to Wiki as well if worthwhile.
-----
Using the Noise Gate -- Matt's Tips & Tricks
There are three basic approaches to using the noise gate, depending on what type of music or effect you are pursuing. Remember that the noise gate is “intelligent” and uses technology to detect and assess incoming signals and signal decay. A good starting point is a Ratio setting around 2.00 (compared to Factory standard of 1.00)
Approach #1: The Basic, Gentle Noise Gate to Control Noise/Silence -- Setting it Up
Grab your hottest, loudest output guitar. Start with Ratio at 2.00, all other noise gate settings at factory default.
Then slowly turn the “Threshold” control UP until any noise is gone. Then play and check when you hold a note or chord. Check -- does the decay “feel” right? Adjust up or down.
If you want a more gradual noise gate, just increase the Release. Keep checking to make sure the decay is “gradual” rather than abrupt.
If you need a sudden attack on the noise gate, reduce the Attack value to 1 ms.
Approach #2: Noise Gate as a Dramatic Effect
Some artists like a dramatic “burst” of noise that can disappear just as fast. Metal players like this for riffing for example. To get that dramatic effect, turn the Ratio control up to 4 or even 8. Shorten the Attack from factory default, which you gives you more of a “burst” of sound. Then shorten the Release time to get a more dramatic “chop” at the end of what you play. Finally, use the Threshold to dial in the sweet spot, when you are NOT playing.
Approach #3: Subtle Noise Reduction
This approach is just to ease the volume of hiss, but still leaves a trace of it. Use factory settings to start, then reduce Ratio to zero, then bring it up slowly to 1.2, or 1.3. Second, set the release very slow in milliseconds.
So those are three ways to approach the powerful AXE II noise gate -- whether to eliminate noise, or use it make chords punchy and choppy (palm muting for example), or reduce the background noise of amp hiss.