Something I have found very handy is that on the Home screen, knobs D and E display your current view and layout numbers, and turning the knobs cycles through them. So anytime you seem "lost" check those. As I was getting my head around customizing all my layouts with layout links etc that was helpful when testing things. "Oh crap, now I'm on my effects layout and no switch to go back to presets" or whatever. Or I'm just messing around with stuff and decide I want to jump right to MLM - twist that E knob.
And remember, layouts are only about what the 3 footswitches do. It's not a "mode" or sound altering thing. You can reassign them however you like.