I'd highly recommend buying a chambered guitar. The older I get, the more I appreciate them, both for weight & tone.
There have never been more options to choose from as there are these days.
I do my chambering for weight reduction to the body along w/ achieving a more hollow body effect for the neck pickup.
Fret scale divided by 16 will give you one of the many ways of finding harmonic sweet spots & pickup locations based on Bill Bartolini's research.
(This is one way to go about finding multiscale intonation points & pickup coil locations also)
I based these around what I wanted in a guitar:
Tight & thick bridge pickup response for rock & metal heads. I leave the body solid around the bridge pickup.
Nice & fat neck position where the top coil of the neck pickup is directly under the 24 fret sweet spot. When the neck pickup hole is routed in the top, it connects directly into the chamber.
Some people put the middle of the humbucker in these 'sweet spot' locations, I prefer an actual coil to be there when using split pickups.
The circles in the chambered areas are for reinforcement during it's life as a guitar & also so it doesn't collapse when I vacuum press the top on.
Since the guitar is chambered, I decided to hollow out the circles for the additional weight.
The reason I went w/ the circles are because they're a more gentle shape compared to a square. I tried using square reinforcement blocks at first, but I could see little creases in the top after they were vacuum pressed. I went for the softer shape & the problem was resolved.
Enjoy your quest for the ultimate tone!