That has worked great for me, (I take no credit for this as I have learned from other's posts), and I use mostly real cabs on stage.
I removed the EQ block I had in the beginning of the chain and added a filter block, (very first slot). The EQ block was killing the fullness and tone. I set the filter block to hipass and set 110 low and 4999 high, with all other settings default, (this can be adjusted to taste). I left the EQ block flat in the amp block. In the speaker section of the amp block, I set the low res freq to 110 and low and high resonance to 1, and left all other defaults. Flattening the low and high resonance really helped with the booming lows and glass breaking highs. I set my cab block to match my 4 x 12 cab which is 75hz to 5000 and changed from hi res to normal setting, (you can adjust this to taste as well). I set the EQ, brightness, etc to my liking, in the amp block. Not only did my cab come back to life making the tone very balanced and rounded, but FOH sounds less hollow and more balanced and manageable. I now have tight lows and controllable highs, without the boom and ear piercing highs. I then copied my presets to a second and third set and tweaked the filter block and amp speaker section, for my 2 x 12 open back cab and FRFR cab.