I received my Axe II a couple of days ago, and was getting intermittent clicks/pops while playing it via SPDIF through my Focusrite Saffire 56 interface. When I changed the clock source on the Saffire to SPDIF the noise disappears. Haven't tried recording yet. Not sure that is going to help the USB issue, but thought I'd share the experience. Have to add that it really is a fantastic sounding processor!