I've been thinking about this pairing as well. Still mulling it over as it is not readily available yet. Here is my take:
Sounds like you all figured out the topology stuff and now know it's a hybrid amp in the sense of modeling front end, tube power amp section (if you keep the MV pushed in) through a ported cab design with a fairly neutral speaker.
I have played the DT50 and was not impressed, but I did not get a chance to really demo it hard. It was quite bland IMHO as a versatile amp and I didn't gel with any of the four channels. But, it would make sense to try it again or better yet, the DT25. What intrigues me about the 25 is lower cost, lower weight, size but still enough to carry a gig. IF (and that's a big if) the 25 sounds good by itself, it could also be used as intended with the pod hd300 for a really versatile grab and go rig. And IF the FX loop is implemented well the AxeFX into the return might be really cool as well.
I owned the Tweaker and the Mesa TA15. The Tweaker was pretty cool for the money, but felt bland and raw at the same time, just not my style. The TA15 was really neat, the Vox side and Tweed cleans were very nice, I did not dig the gainier sounds and it doesn't have a loop so no real good integration with AxeFX.
All this being said I am looking closely at the new VHT 12/20 amp.
$500 (maybe less), handwired on eyelet board and simple circuit (made in China), supposedly purpose built for pedal users including a 9v tap for pedal power. Variable wattage control, can take 6v6 or EL84 @12 watts or 6L6 or EL34 @20 watts, tube buffered fx loop with send and receive levels supposedly able to handle rack gear and pedals very well. Depth and texture controls post fx loop return to allow additional tone tweaking if required. 1x12 is 45lbs and about 20x20x10.5", also comes in head form. Oh yeah, has a pull boost that also using a footswitch to get more grunt and gain as well. So, small jam just take the amp, footswitch and maybe a pedal or two (powered via the amp), for a bigger gig, AxeFX into the fx return.
On paper, sounds great. In reality, who knows?
I'm going to try and check this out from a store that has a liberal return policy.
Why this is appealing to me vs. Just AxeFX plus frfr is that it might be easier to carry, I could leave the AxeFX racked in the studio if it's not called for, I also believe in having a tube amp around for reference and.....I still like tubes too! I mean, it's less than the cost of a used Mesa power amp, worth a shot IMHO.