First of all, the unit deserves the good reviews it gets. Because it's a great device, and I think it was the first of it's kind. But it is important to understand what kind exactly. It is, first and foremost, a loadbox and an attenuator - I.e. it was created for playing music at low volume while cranking up your power amp. It can also help playing louder if you have a lunchbox 20 watt amp with a crappy power amp inside. As such, the device can serve as a standalone power amp, of course, and a good one at that - it is compact and relatively lightweight compared to other options, and it may be excellent for axe, especially at bedroom volumes.
However, if you crank it up, it'll still behave like a tube amp, it'll start clipping and compressing, there's no way around it. So if you rely on power amp modeling, this may be a problem. You play blues, this means that you probably use vintage amp models, and they rely on power sections for their sound a lot, so you can't just turn that off. At certain volumes, this may be somewhat of a problem. Although, of course, it doesn't mean you won't like it, but who knows. It's hard to judge without trying - I certainly don't know what you call loud or not loud. But I think that the Matrix will be a safer choice.
Note that it's just my opinion though, and I'm some random guy from a forum.
Regarding speakers, I honestly have no idea, I personally never owned a cabinet, don't plan to, don't need one, and don't use any FRFR speakers apart from a couple if studio monitors. I do use cabinets on stage sometimes, but that's just for feedback/feel, and I'm happy with any 4x12 available. We stopped using cabinets during rehearsals (which is a real blessing), and I certainly don't have one at home. Sorry.