I run a modeler or sometimes a real amp, through a load box, into an IR cab sim, back into the front of a tube amp and play it through the amps 1x12 speaker and it sounds great, best of both worlds tone. Heck sometimes even mic that cabinet then lol
IR is basically an EQ and the real speaker is an eq of sorts as well since it rolls off the highs and lows to some degree. The tone stack of the amp and voicing also colors the tone, in my case, using a blackface style tone stack, and an all tube power section.
Should work but it sounds better than any FRFR speaker or monitor as they don’t sound “real” and in the room, and a guitar cab on its own doesn’t sound enough like an album it mic’d cab, so the unlikely solution is to play a mic’d cab sound through a real speaker. Sounds huge and in the room and like an album all at once.
I’ve gone back and forth with a bunch of cabs on their own, monitors on their own, you name it and always come back to using my ToneKing Gremlin with a Alnico Cream 1x12 as the best my guitar has ever sounded