Like any effect, like reverb, sometimes less is more. But, the enhancer block used for the IEM's can give a wider stereo field in your mix.
Here is what has worked for me (after playing around with Reverb/Enhancer with my IEM mix.
I run three 'inputs' into my Axe III, and use the mixer block (and effects) to send the perfect mix to my IEM.
My guitar goes to FOH with appropriate effects (directly from Axe)
My vocal goes to FOH dry....and is split to also go into my Axe (dry).
Band IEM mix comes from FOH (dry) and goes into my Axe.
Now, in my Axe.
Input 1 - Guitar (with any effects I happen to use for each song)
Input 2 - Vocal (with a Reverb added in the Axe FX...just for my IEM mix)
Input 3 - Band (from mixer - with no vocal or guitar) -with a stereo enhancer added in the Axe.
I blend these 3 signals using the mixer block.
I put the stereo enhancer on the FOH feed with the band (drums/bass/other vocals) - so that it gives a nice stereo spread
I add Fractal Reverb to my vocal and no stereo spread (so it's right down the middle) - with this I hear my vocal clearly, helps me stay in key, and the Reverb is just a great addition to remove the sterile-ness from IEMs.
My front panel performance controls are 5 knobs:
1- Guitar volume going to IEM
2- Vocal volume going to IEM
3- Band mix going to IEM
4- Vocal Reverb mix to IEM (allows me to quickly make it more dry or wet, which helps on different stages)
5- Stereo Enhancer mix (which is on just the FOH band input), to let me tweak the 'width' of the band signal in my ears...again, I may change this based on how things sound in my IEMs on a given stage/night
This set up gives me the most control, when I cannot mix my IEMs myself (some venues don't let me connect my ipad)