I just had an interesting (to me at least) thought. I also play in stereo, and always have. 10-15 years ago I ran dual Marshals or Carvin V3's in stereo. Now I normally run dual CLR's, and a stereo IEM setup.
That said... on stage it doesn't work as well as I'd like, and lately I have run mono more and more often I just need the focus and clarity of a single cutting tone so I can hear what I'm doing above the band. (We have 7 members, and a lot happening, and it's pretty loud. We play decent clubs with tons of subs and bass rumble and all of that, and hearing clearly is always a challenge for me.) I've been stacking my CLR's like a backline amp and running everything down the center for maximum cut and punch to get through all of the voices, keys, bass, percussion and all of the noise on stage.
I also have to take care to make my sound kind of "half stereo". I pan some differences in, and do some delay work, but you have be be careful that people on one side or the other of the room can still hear what you are playing, so you can't go all out with the stereo effects live in a big club. (You can in a smaller club, that is somewhat narrow or deep where you bring your own PA and can control it better, but in wide places the sound just doesn't work out that well)
At home practicing, (being a bedroom player) stereo is SO much more enjoyable. I actually prefer headphones above all else in that environment. There is nothing like jamming to tracks or recording or learning songs in quality cans for me. I can hear details that I would never otherwise hear. Oh how I wish I could ever get that on stage...