Personally, I use all 8 scenes because I like to have dry options with X/y amp choices and x/y drive choices.in scenes 1 through 4 Then I like to use scenes 5 through 8 to have different effects changes with x/y block switching already programmed into each scene under foot. Then I just get my sound with one tap & minimal thinking.
As a second approach to scenes, if I am using them for jamming or performance, I will usually make a copy of a desired preset, re-order the scenes, delete the scenes I don't need and see if I need other variations or repetitions under foot as scenes, so that I can just use scene change up and down buttons or the turn the twisty knob at the front of the unit to get what I need with minimal tap dancing or knob turning.
When building companion preset/cab combos in my "interesting amp pairings" folders in the impulse response Cab Packs I sell, I use the first approach I talked about.