Humbuster uses a 3-conductor cable. The extra conductor needs to be connected to the shield, at the receiving-equipment end. That extra conductor picks up the same ground noise that the rest of the cable does. The Axe-Fx reads that noise from the ring connection on its jack. Then it sends the same noise back down the cable, except that it's out of phase. The idea is thta the out-of-phase noise will cancel out the in-phase noise.
Bottom line: the extra conductor needs to be connected to the shield at the receiving equipment end. If that happens inside the jack, that's great. But it's not likely. A TRS input at your mixer won't connect them together unless the manufacturer provides a way to make that happen. It won't happen with a TS jack, either. A TRS-to-XLR cable won't do it. Neither will a TRS-to-TRS jack cable. And humbuster won't work if the receiving equipment has a balanced input.
Bottom bottom line: if you're not comfortable making the cable yourself, follow 8string's advice: take your manual to a guitar shop or repair place, show them the picture, and ask them to make you one.